제조사 : 에코먼트

브랜드 : 닥터디퍼런트

효능 · 효과 

주름개선 기능성화장품

● retinyl palmitate

● Hydroxypinacolone retinoate

닥터오라클 레티노타이트닝 앰플

■ 먹는 레티노이드 제품

● Vitamin A(레티놀)

● isotretinoin(여드름약)

로아큐탄 이소티논연질갭슐 아키놀연질캡슐

● etretinate(건선약)

티가손

● acitretin(건선약)

네오티가손

# 레티노이드의 피부노화 관련 효과 

Epidermal cells renewal 

Inhibit keratinocyte differentiation and to stimulate epidermal hyperplasia

Extracellular matrix production

Inhibition of UV-induced extracellular matrix degradation

Cytokine modulation – angiogenesis

Melanocyte function modulation

Oxidant/antioxidant 

Prevention of UV-induced vitamin A deficiency 

Sunscreen effect

# 레티노이드의 피부노화관련 효과 기전

Inside the cells, they bind to nuclear receptors (RAR-α, -β, -γ, and RXR-α, -β, -γ) then the ligand-receptor complexes modulate the expression of genes involved in cellular differentiation and proliferation (1–3). Retinol is produced in the small intestine either by hydrolysis of retinyl esters, or by oxidation of various carotenoids (4–6). Retinol can be oxidized into retinaldehyde, and then into retinoic acid, the biologically active form of vitamin A (FIG. 1). On the other hand, retinol can be esterified with fatty acids to form retinyl esters (2,7,8). In the blood and tissues, the two predominant endogenous retinoids are retinol and its esters. Retinoids are present in the skin: retinol and retinyl esters account for more than 99% of total cutaneous retinoids, i.e., approximately 1 nmol/g, whereas retinaldehyde and retinoic acid are under the limit of detection (10 pmol/g) (9–11). Retinoic acid is catabolized either by phase I or phase II enzymes, giving rise to retinoyl glucuronide or 4-oxoretinoic acid (12,13).

The present authors have previously shown that topical application of retinaldehyde increases the expression of CD44 in mouse skin. The increased expression of CD44 accompanying epidermal hyperplasia induced by topically applied retinaldehyde is associated with an increase in epidermal and dermal hyaluronate and with increased expression of hyaluronatepolymerizing enzymes, hyaluronate synthases 1, 2, and 3 (31). 

레티노익애시드의 유전자에 대한 효과는 

prevention of matrix metalloproteinase activation

prevention of oxidative stress

and the regeneration of extracellular matrix

# 레티노이드의 여드름 관련 효과